Heddrite

Doctor D's Resume

Paolo B. DePetrillo, M.D.

 PROFESSIONAL EXPERIENCE

                        SNBL Clinical Pharmacology Center, Inc.

                        Baltimore, MD 21201

                        Medical Director

                               

 CONCURRENT POSITIONS

 Partner

Applied Pharmacogenomics, LLC, Bethesda, MD, USA

Telemedicine Consultant 

Internal Medicine and Clinical Pharmacology MDLive

ACTIVE MEDICAL LICENSES

Rhode Island, Massachusetts, and Maryland

EDUCATION

Brown University Providence, RI, USA: Sc.B., Biology, MD

POST-GRADUATE TRAINING

 Clinical Pharmacology Fellowship                                        

(Paul Calabresi, MD & Darrell R. Abernethy, MD, PhD)

Brown University/Roger Williams Hospital

Internal Medicine Residency                                                  

Brown University/Roger Williams Hospital

POST-GRADUATE HONORS AND AWARDS

 Pharmaceutical Manufacturers                                             

Association Foundation Faculty

Development Award

Public Health Service Achievement Award                          

(Clinical Excellence)

Public Health Service Hazardous Duty Award                        

Pfizer Clinical Pharmacology                                                

Fellowship Award

MILITARY SERVICE

 United States Public Health Service Commander (O-5) Active Reserve

United States Public Health Service Commander (O-5)

  

BOARD CERTIFICATIONS

American Board of Clinical Pharmacology                          

Certificate Number 93144

American Board of Internal Medicine

Certificate Number 100003                                                      

 

PAST ACADEMIC APPOINTMENTS

Adjunct Associate Professor                                                  

Wake Forest University Health Sciences

Dept of Physiology & Pharmacology

Medical Center Boulevard

Winston-Salem, NC  27157-1083 USA

Senior Research Investigator                                                                                              

Section on Clinical and Biochemical Pharmacology

Laboratory of Clinical Studies

National Institute on Alcohol Abuse and Alcoholism

National Institutes of Health

Bethesda, MD, USA

Assistant Professor of Medicine                                             

Brown University

Chief Medical Resident                                                          

VAMC/Brown University

Providence, RI, USA

PAST HOSPITAL APPOINTMENTS

Medical Staff                                                                           

Warren Grant Magnuson Clinical Center

National Institutes of Health

Bethesda, MD

Medical Director                                                                     

Substance Abuse Treatment Center

Roger Williams Medical Center

Providence, RI, US

Active Medical Staff                                                               

Roger Williams Hospital

Associate Active Medical Staff                                               

Roger Williams Hospital

Senior Assistant Surgeon                                                        

Lewisburg Penitentiary Hospital

United States Public Health Service

Lewisburg, PA, US

PAST CLINICAL APPOINTMENTS

Staff Physician                                                                        

New Bedford Area Center for Human Services

Drug Treatment Program

New Bedford, MA,USA

OTHER APPOINTMENTS

Data Monitoring Board for Cooperative Study 1008, “A Multicenter Efficacy/Safety Trial of Buprenorphine for Treatment of Opiate Dependence                                                           

Ad Hoc Committee for the NIDA/VA Substance Abuse Medication Development Research Units Substance Abuse Committee  

American Society for Clinical Pharmacology and Therapeutics

HOSPITAL COMMITTEES

Human Subjects Institutional Review Board (National Institutes of Health, NINDS)

Human Subjects Institutional Review Board (National Institutes of Health, NIAAA)

Human Subjects Institutional Review Board,  Clinical Affairs Committee, and Clinical Competency Committee (Roger Williams Hospital, Brown Univ)                                  

                                            

PUBLICATIONS

  1. Swift RM, Dudley M, DePetrillo PB, Camara P, Griffiths W. Altered methadone pharmacokinetics in pregnancy: Implications for dosing. J Subst Abuse 1:453-460, l989.
  1. DePetrillo PB, Swift RM, Ambroise C, Abernethy DR. High- performance liquid chromatographic determination of 3':5'cyclic adenosine monophosphate in human platelets. J Chromatogr  527(2):421-427, l990.
  1. Swift RM, DePetrillo PB. Human leukocyte beta-adrenergic stimulated cyclic AMP in ethanol intoxication and withdrawal. Alcohol Clin Exp Res 14(1):58-62, l990.
  1. Swift RM, DePetrillo PB. Cocaine abuse and dependence. RI Med J 73(6):265-70, 1990.
  1. DePetrillo PB, Swift RM. Ethanol exposure results in a transient decrease in cAMP in human platelet cAMP levels: Evidence for a protein kinase C mediated process. Alcohol Clin Exp Res 16(2):290-294, l992.
  1. DePetrillo PB, Kurl RN. Stimulation of protein kinase C by 2, 3, 7, 8- tetrachlorodibenzo-p-dioxin (TCDD) in rat thymocytes. Toxicol Lett 69(1):31-36, 1993.
  1. DePetrillo PB, Liou CS: Ethanol exposure increases total PKC activity in human lymphocytes.
  1. Kurl RN, DePetrillo PB, Olnes MJ: Inhibition of Ah (dioxin) receptor transformation by 9-hydroxy ellipticine: role of protein kinase C. Biochem Pharmacol 46(8):1425-1433, 1993.
  1. DePetrillo PB, Butte AJ. Derivation of a scale-independent parameter which characterizes genetic sequence comparisons. Comput Biomed Res 26:517-540, 1993.
  1. DePetrillo PB, Abernethy DR, Wainer IW, Andrawis NS. Verapamil decreases lymphocyte protein kinase C activity in humans. Clinical Pharmacol Ther 55(1):44-48, 1994.
  1. DePetrillo PB. Effects of chronic alcohol use and age on human lymphocyte protein kinase C activity. Pharmacol Biochem Behav 48(4):999-1004, 1994.
  1. DePetrillo PB, Rice, JM. Methadone dosing and pregnancy: Impact on program compliance. Int J Addict 30(2) 207-217, 1995.
  1. DePetrillo PB: Calcium-activated neutral protease activity is decreased in PC12 cells after ethanol exposure. J Neurochem 68:1863-1869. 1997.
  1. DePetrillo PB, White KV, Liu M, Hommer D, Goldman D. Effects of alcohol use and gender on the dynamics of EKG time-series data.  Alcohol Clin Exp Res 23: (4) 745-750, 1999.
  1. DePetrillo PB, Speers D’A, Ruttiman UE. Determining the Hurst exponent of fractal time series and its application to EKG analysis. Comput Biol Med 29:6, 393-406, 1999.
  1. DePetrillo PB, Bennett AJ, Speers d’A, Suomi SJ, Shoaf SE, Karimullah K, Higley JD. Ondansetron blockade of ketamine-induced effects on electrocardiographic signal dynamics in rhesus monkeys. Eur J Pharmacol 391:(1-2), 113-119, 2000.
  1. DePetrillo PB, Yang Q, Rackoff J, SanMiguel A, Karimullah K. Surface fractal computation and its application to immunofluorescent histochemical studies of calpain and calpastatin in PC12 cells. J  Neurosci Meth 103(2):191-197, 2000.
  1. Karimullah K, George DT,  DePetrillo PB. The time-course of electrocardiographic interbeat interval dynamics in alcoholic subjects after short-term abstinence. Eur J Pharmacol  427(3): 229-235, 2001.
  1. Rackoff J, Yang QF, DePetrillo PB. Inhibition of rat  PC12 cell calpain activity by glutathione, oxidized glutathione and nitric oxide.  Neurosci Lett 311(2): 129-132, 2001.
  1. Bennett AJ, Sponberg  AC, Graham T, Suomi  SJ, Higley  JD,  DePetrillo PB.  Initial alcohol exposure results in decreased heart rate variability in alcohol-naĢve rhesus monkeys.  Eur J Pharmacol 433:169-172,  2001.
  1. Wan W, DePetrillo PB. Ritonavir inhibition of calcium-activated neutral proteases. Biochem Pharmacol 63(8):1481-1484,  2002.
  1. Wan W, DePetrillo PB. Ritonavir protects hippocampal neurons against oxidative stress-induced apoptosis. Neurotoxicology.  23(3):301-306, 2002.
  1. DePetrillo PB. Calpains - A review of the recent patent literature. IDrugs. 5:568-576, 2002.
  1. Li XW, DePetrillo PB. Corticosterone increases 5-HT3 receptor mRNA in PC12 cells. Neurosci Lett 331(2):143-145, 2002.
  1. Herman AI, Philbeck JW,  Vasilopoulos NL,  DePetrillo PB. The serotonin transporter promoter polymorphism and differences in alcohol consumption behaviour in a college student population.  Alcohol Alcohol 38(5):446-449,  2003.
  1. Bennett AJ, DePetrillo PB.  Sex differences in total body water in rhesus macaques estimated by ethanol dilution. J  Med Primatol 33(3):163-166, 2004.
  1. Herman AI, Kaiss KM, Ma R, Philbeck JW, Hasan A, Dasti H, DePetrillo PB. Serotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking risk in young women. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133(1):74-8.
  1. Fontenot MB, Padgett EE 3rd, Dupuy AM, Lynch CR, De Petrillo PB, Higley JD. The effects of fluoxetine and buspirone on self-injurious and stereotypic behavior in adult male rhesus macaques. Comp Med. 2005 Feb;55(1):67-74.
  1. Bennett AJ, DePetrillo PB. Differential effects of MK801 and lorazepam on heart rate variability in adolescent rhesus monkeys (macaca mulatta). J Cardiovasc Pharmacol. 2005 May;45(5):383-8.
  1. Sabetta JR, DePetrillo P, Cipriani RJ, Smardin J, Burns LA, et al. (2010) Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults. PLoS ONE 5(6): e11088. doi:10.1371/journal.pone.0011088

ABSTRACTS

  1. Swift RM, DePetrillo PB, Brown WA, Liepman M, Nirenberg TD. Human lymphocyte beta-adrenergic activity in ethanol withdrawal. Presented at Am. College Neuropsychopharmacology Meeting, l986.
  1. Swift RM, DePetrillo PB. Effect of ethanol on human mononuclear cell cyclic AMP formation. Clin Research 34(2):407A, l986.
  1. Swift RM, DePetrillo PB, Dudley M, Griffiths W, Dextraze P. Altered methadone pharmacokinetics in pregnancy with twins. Clin Pharmacol Ther 41(2):231, l987.
  1. Swift RM, Sullivan JT, DePetrillo PB. An open study of clonidine detoxification in the general hospital. Clin Pharmacol Ther 43(2):l86, l988.
  1. DePetrillo PB. Dynamics of plasma adenosine during ethanol withdrawal. Clin Research 40:410A, l992.
  1. DePetrillo PB, Peterson D. Effect of magnesium sulfate on alcohol withdrawal symptomatology. CLIN PHARMACOL THER 51: (2) 169-169 FEB 1992
  1. DePetrillo PB, Kurl RN. 1,2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) stimulates protein kinase C (PKC) activity in immature thymocytes. FASEB J 6: (5) A1885-A1885 Part 2 FEB 28 1992
  1. DePetrillo PB, Andrawis NS, Abernethy DR. Verapamil (VER) decreases lymphocyte protein kinase C (PKC) activity in humans. The Pharmacologist. 34(3):91, l992.
  1. DePetrillo PB. Alterations in circulating lymphocyte protein kinase C (PKC) activity associated with chronic alcohol exposure. Clin Pharmacol Ther. 53(2):176, 1993.
  1. Kurl RN, DePetrillo PB, Olnes M. Role of phosphorylation in transformation of the Ah receptor-effect of 9-hydroxy ellipticine an inhibitor of protein kinase C (PKC). Proceedings of the American Association for Cancer Research. 34:176, 1993.
  1. DePetrillo PB. Ethanol inhibits calcium-stimulated protease activity. Clin Pharm Ther. 61(2):190, 1997.
  1. DePetrillo PB. Calcium-channel blockers prevent ethanol-induced decreases in calpain activity in PC12 cells. CLIN PHARMACOL THER 63: (2) 204-204 FEB 1998
  1. DePetrillo PB, Ruttimann U. Method for determining the Hurst exponent of a fractal time series and its applications to EKG signal analysis. Clin Pharm Ther. 65(2):158, 1999.
  1. DePetrillo PB, White KV, Liu M, Hommer D, Goldman D. Alcohol consumption is associated with decreased cardiac signal complexity.  Clin Pharm Ther. 65(2):158, 1999.
  1. Graham S, Umhau J, DePetrillo PB. Hurst and RSA measures in healthy controls, alcoholics, and perpetrators of domestic violence. RSA 1999.
  1. Bennett AJ, DePetrillo PB,  Shoaf  SE, Lindell  S, Shannon  CS, Suomi  SJ, Higley  JD. Interindividual differences in CSF 5HIAA concentrations alter rhesus monkeys' cardiac signal complexity in response to serotonergic agents.  American College of Neuropsychopharmacology, Acapulco, Mexico. 1999.
  1. Krupnick S, Peterson DJ, McDonough MK, DePetrillo PB:. The typology of alcohol withdrawal syndrome (AWS): implications for diagnosis and treatment. 6th Annual NPNR Conference. 19:2000.
  1. Bennett AJ,  Sponberg AC, Graham T, Lindell  S, Suomi  SJ, Higley JD,  DePetrillo PB. Initial alcohol exposure results in stress-dependent acute increases and subsequent decreases in CSF 5-HIAA concentrations and cardiac signal complexity in alcohol-naĢve rhesus monkeys. Presented at the annual Experimental Biology meeting, Orlando, FL. 2001.
  1. Hibbeln JR, DePetrillo PB, Champoux M, Higley JD,  Lindell  S,  Shannon C, Suomi SG,   Salem N.  Improvements in heart rate variability among adolescent rhesus monkeys fed formula supplemented with DHA and AA as infants: Neuropsychiatric implications. Inform 11(5), 2000.
  1. Yang QF, DePetrillo PB. Calpain inhibitor and ritonavir block glutamate cytotoxicity in PC12 cells. MOL BIOL CELL 11: 411A-412A Suppl. S DEC 2000
  1. Graham TA, Bennett AJ, Lindell SG, DePetrillo PB, Higley JD. A single alcohol exposure changes heart rate variability in rhesus monkeys. ASP 2000.
  1. Graham T, Bennett AJ,  Lindell S,  Sponberg AC, DePetrillo PB. Change in cardiac signal dynamics associated with MK-801 and lorazepam in rhesus monkeys. 24th Meeting of the American Society of Primatologists, Abstract number 59, 2001.
  1. Depetrillo PB, Wan W. Ritonavir Is A Competitive Inhibitor Of Calcium-activated Protease (Calpain) Activity In PC12 Cells.  CLIN PHARMACOL THER 69: (2) P36-P36 Suppl. S FEB 2001
  1. Bennett AJ,  Sponberg  AC, Graham T, Lindell S, Suomi SG, Higley JD, DePetrillo PB.  Initial alcohol exposure results in stress-dependent acute increases in CSF 5-HIAA concentrations and cardiac signal complexity in alcohol-naive rhesus monkeys. FASEB J 15: (5) A911-A911 Part 2 MAR 8 2001
  1. DeVinney BJ, DePetrillo PB, Yang JJ, Morin LC, Suomi SJ. CSF 5-HIAA and HVA associated with weaning aggression among rhesus monkey mothers at the N. I. H field station. ASP 2002.
  1. Bennett AJ, Garrett-Goodyear CH, Higley JD, DePetrillo PB. Cardiac reactivity as a predictor for response to alcohol in rhesus monkeys. Alcohol Clin Exp Res. 2002 26(5):180A (1049).

OTHER PUBLICATIONS

 

  1. Abernethy DR, DePetrillo PB: Withdrawal from non-abused drugs. In Encyclopedia of Drugs and Alcohol, New York, Macmillan, Inc. 1993.
  1. Olnes MJ, DePetrillo PB, Kurl RN: Mechanism of 9-hydroxy ellipticine induced inhibition of hepatic aryl hydrocarbon hydroxylase. In Cytochrome P450. 8th International Conference, Paris, John Libbey Eurotext, 1994:729-732.
  1. DePetrillo PB, McDonough MK. Alcohol Withdrawal Treatment Manual. FTS. Glen Echo, MD, USA 1999.

SELECTED MANUSCRIPTS IN REVIEW

  1. DePetrillo PB. Relationship of solar cycles to influenza A epidemics from 1734 to present.

SELECTED MANUSCRIPTS IN PREPARATION

  1. DePetrillo PB. Bootstrap resampling routines for determining the power of genetic association studies.
  2. DePetrillo PB. Underestimates of the magnitude of the Type I error in allelic frequency-based analyses of case-control data in genetic association studies demonstrated by bootstrap resampling.

REVIEWER

Alcohol and Alcoholism; Alcoholism Clinical and Experimental Research; American Journal of Cardiology; American Journal of Medical Genetics; Archives of General Psychiatry; Clinical Pharmacology and  Therapeutics; European Journal of Clinical Pharmacology; Journal of Pharmacology and Experimental Therapeutics; Life Sciences; Neuroscience Letters; Pharmacological Reviews; iDrugs

PATENTS

Determining the Hurst exponent of time series data

 U.S Patent No. 6,144,877 (2000)

Methods of and compounds for inhibiting calpains

U.S Patent No. 6,448,245 (2002)

 

 

RESEARCH EXPERIENCE